Mild Cognitive Impairment (MCI) with Neuroimaging-biomarkers allows for an early diagnosis of Alzheimer'sdisease in the preclinicalstages. In patients with late-onset Alzheimer's disease, researchers usedstructural and functional magnetic resonance imaging (MRI), advanced MRItechniques (diffusion tensor imaging, magnetic resonancespectroscopy, and perfusion), positron emission tomography with CSF protein levels, fluorodeoxyglucose, amyloidtracers, and other neurochemical tracers. These imaging biomarkers' complextests are used to predict disease development early on and improve theassessment of therapeutic efficacy in these diseases in future clinical trials.
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