Neuroepigenetics is the field in Neurobiology that replaces the conventional thoughts on heritable epigenetic mechanisms, which involves in histone and chromatin modification which results in the variable expression of genes in the CNS. The numerous Neuroepigenetic mechanisms have been involved in several neurological and neurodegenerative diseases for the regulation of various epigenetic mechanisms. All the mechanisms in epigenetics will have a biochemical characteristic such that it helps in the regulation process. The basic principle of Neuroepigenetics is that once DNA methylation patterns are established upon the genome in terminally differentiated cells, those modifications are permanent and essentially immutable. Other epigenetic molecular mechanisms are also in play in neurons. Some are ATP-dependent chromatin remodelling, genomic imprinting, SNF2 chromatin remodelling.